Neurosurgery is a planned intervention in a complex anatomical space. The success of an operation is determined by two factors: The choice of the best route to the surgical target and the surgical technique at the target itself.
Every patient and every operation is unique and the smallest anatomical nuances can have enormous significance during the course of an operation. Therefore the spatial details of the surgical site must be analysed and understood very precisely before an operation. The basis for the planning process is high-resolution imaging: MRI to depict soft tissue, f-MRI to identify speech or motor functions, MRI/DTI for white matter tracts, CT for bony details of the skull base or to show calcifications of aneurysm or tumours, X-Ray angiography, CTA or MRA for vascular anatomy or PET-scans to visualize metabolically active tumour tissue. Especially in the case of complex operations, all these imaging series are fused, processed and displayed in a Virtual Reality simulator. The surgical strategy, including the use of specific techniques and instruments, is then planned within this simulated 3D scenario. The aim in each and every case is to identify the ideal approach: with a bone window and skin incision as small as possible but as large as necessary - always taking into account that the surgical corridor circumvents critical structures and provides sufficient space for precise and gentle tissue manipulations.
During a minimally invasive operation, instruments are used which enable the operation to be performed precisely and in smallest space. In addition to a stereoscopic operating microscope an endoscope is often used to illuminate and view the surgical filed.
With variable viewing angles endoscopes allow inspecting areas that lie beyond the straight viewing axis of the operating microscope, in other words they allow viewing “around the corner”. This is for example very helpful to identify small vessels or nerves that are hidden behind tumour tissue in order to move them aside and preserve them. In selected cases in the area of the base of the skull, modern endoscopic neurosurgery makes it possible to operate through the nose, so that no skull opening is necessary.
In addition to the surgical microscope, endoscope and fine micro instruments, the minimal invasiveness of neurosurgery is based on computer-assisted navigation and imaging during the operation.
At the Hirslanden Clinic, we have an intra-operative MRI for tumour tissue imaging, an intra-operative CT (bone imaging and bleeding control), ultrasound (online tissue-imaging), as well as intra-operative catheter angiography and ICG angiography for aneurysms, fistulas and AVM surgery at our disposal.
For continuous intra-operative control of important neurological functions, we employ electrophysiological monitoring including direct recoding of brain tissue activity. In selected cases, brain surgery while being awake offers an excellent opportunity to monitor functions such as speech, vision or movement.
Minimally invasive neurosurgery is based on a combination of: Precise and individual surgical planning, microsurgical techniques with sophisticated instruments and state-of-the-art intra-operative imaging and monitoring technology.
These refined synergies, which are continuously and individually being reassessed from patient to patient minimise the risk of surgery and maximise patient safety. They are the key to successful neurosurgery.
The Intraoperative magnetic resonance imaging (MRI) system at Klink Hirslanden has been specially developed for neurosurgery. Coupled to a computer-assisted navigation system it enables an MRI scan to be done at any point during an operation. This is particularly helpful when operating on certain types of brain tumors – allowing to precisely delineate the margin between tumor and healthy tissue.
Current research suggests that using this technique can improve the outcome for patients. In cases of malignant brain tumors, particularly glioblastomas, we use intraoperative MRI in combination with a fluorescent dye (Gliolan) in order to further optimize the likelihood of a maximal resection.
When operating on pituitary tumors, intraoperative MRI offers a valuable adjunct to endoscope-assisted microsurgery, particularly in order to visualize hidden or difficult-to-access parts of the tumor and assist in its definitive and total removal.
The intraoperative computed tomography (CT) at Klinik Hirslanden is integrated with the “BrainSuite” system – a neurosurgical operating room equipped with
At any point during an operation we can perform a CT scan – this is particularly useful in the area of the skull base, for certain brain tumors, for vascular neurosurgery and for selected spine surgery in order to gain precise spatial orientation.
Using CT intraopertively in this way, the precision and thus the safety of an operation can be significantly improved. In operations for spine stabilization, intraoperative CT provides exact confirmation of the position of prosthetic discs or screws, which may be implanted.
Our intraoperative angiography system allows us to perform the most advanced vascular neurosurgery for aneurysms and arterio-venous fistulae or malformations. Every angiographically-assisted operation is performed by an experienced, interdisciplary team of neuroradiologists and neurosurgeons.
Using angiographic monitoring, it is possible to measure particular flow parameters in the blood vessels during the operation, facilitating and optimising intraoperative decision-making, like clip selection and positioning.
Intraoperative electrophysiological monitoring (neuromonitoring) is used to keep track of important neurological functions while operating. In the brain this is especially important when operating near areas, which process motor functions or vision or near tracks of nerve bundles, which convey electrical signals in the deep brain, brain stem or spinal cord. During spinal surgery, especially in complex cases containing scar tissue or during the placements of implants, electrophysiological monitoring is applied to avoid damage to nerves traveling in and next to the spinal canal.
Depending on the structures and functions to be monitored a variety of methods of monitoring are available and often a combination of techniques is applied (Somatosensory evoked potentials (SSEP), Motor evoked potentials (MEP), Acoustic evoked potentials (AEP), Electroencephalogram (EEG), Visual evoked potentials (VEP) and direct tissue micro-stimulation). In all cases a neurologist is present in the operating room to interpret to electrical impulses while they are obtained. In case of tumour surgery, bi-polar or mono-polar micro probes are used to measure functional activity before and while tumour tissue is removed. Comparable to real-time 3D radar, electrical currents are sent from the tip of the stimulation probe into the surgical field in a spherical fashion and with varying intensities, allowing visualization of distances to eloquent structures in all directions and in real time. Especially at tumour boarders or tumour-infiltrated zones, this allows precise differentiation between tumour and healthy tissue.
In nature, bats use ultrasonic waves at a frequency above 20 kHz to locate prey or obstacles. Intra-operative ultrasound is based on the same principle: Waves are emitted by a transducer, reflected individually by tissue structures and detected again by the transducer. In this way different tissues can be visualised. Ultrasound waves are risk-free because, similar to sound waves, they leave no lasting effects in the body.
In neurosurgery, ultrasound allows real-time navigation in the depth of the central nervous system. Ultrasound is used before and after opening of the meninges in order to localize lesions in depth of the brain. During a tumour operation ultrasound enables to visualize and observe the progress of tissue removal in real time.
Intraoperative real-time navigation with ultrasound is a complementary method to intraoperative computer-assisted navigation and can also be linked to it. This is particularly relevant in the event of displacement of brain structures during surgery, which can occur after the drainage of cerebro-spinal fluid (CSF) or the removal of tumour tissue. Intraoperative ultrasound always provides an online and real-time image of tissue, irrespective of its deformation and hence allows for continuous and precise spatial orientation. This is particularly valuable for the detection of tumour borders or anatomical structures such as cortical sulci or ventricles.
For microsurgery of tumours in and around the spinal cord, the use of ultrasound is also enormously helpful: the opening of the dura can be made more precise and, when resecting a tumour in the spinal cord, tumour boundaries can be displayed exactly.
In our center we use most modern and high-resolution ultrasound technology with a series of ultra-sound probes, some of which being so small that they can be placed directly on tissue even inside a small surgical cavities.
Solitary EBV-associated Lymphoma, left parietal, post-central. Minimally invasive trans-sulcar dissection with intra-operative ultrasound.
Computerized neuro-navigation creates an interface for the surgeon between pre-operative imaging and the actual operation. Before surgery 3D MRI (Magnetic Resonance Imaging), CT (Computed Tomography) and catheter angiography diagnostic data are used to produce images of a for example tumor, the skull base or vessels with very high resolution. Already during the 3D planning of the operation, we assess the position of the target area in relation to other important structures that we want to protect during the operation, such as important nerve tracts (represented in the MRI by fiber tracking), speech areas, motor areas or venous and arterial supplying vessels of the brain.
During the operation, the patient's head is fixed in a suitable position and the processed 3D data from the surgical planning procedure are brought into alignment with the head surface. This is done with the help of a laser detector. The stereo camera of the navigation system detects the position of the head in 3D space and an algorithm automatically performs an exact co-registration between the virtual 3D data of the surgery planning and the actual surgical area.
Once this process is completed, we are able to display the current point of surgery in relation to the surrounding brain structures at any time during the operation, using a tracked instrument or a laser beam in the center of the optical axis of the microscope. If intra-operative MRI or CT is employed, that data may also be directly fed into the navigation system. The risk of an operation can thus be kept to a minimum, since the route to the surgical target area is optimized, risky areas are recognized early and injury to essential structures is avoided.